Abou El Enein founded the Cleopatra Group in 1983, which began as a ceramic business with a single factory. Cleopatra Luxury Hotels & Resorts falls under its tourism wing. It has resorts in Sharm Sheikh, Makadi Bay, North Coast Sidi Heneish, and Marsa Alam. He is also president of the Egyptian-European Business Council, the Egyptian-Portuguese Business Council, the Arab Investors Union, and the General Division of Investors of the General Federation of the Egyptian Chambers of Commerce. Abou El Enein was elected deputy speaker of the Egyptian House of Representatives in 2021 and has been a member of the People’s Assembly of Egypt since 1995.