Khoury assumed his current role in 2012, having joined American Express Middle East in 1989. The company’s “Shop Small” campaign was established in Bahrain in 2021 and introduced in Qatar in January 2024, encouraging card members to buy from and support local businesses. Khoury is a member of the Young Presidents Organization and the Premier Chief Executive Leadership Organization. He sits on the board of directors of the Bahrain International Circuit. He was previously CEO of American Express Saudi Arabia.