Al Fayyadh assumed his current role in 2017. In 2023, KFSH&RC welcomed over 42,000 new patients across its three branches in Riyadh, Jeddah, and Madinah—9% more than in 2022—while outpatients totaled 1.9 million. In July 2024, KFSH&RC and the King Abdullah University of Science and Technology announced that they developed a new gene sequencing system, NanoRanger, for genetic diseases of an unknown mutation. Al Fayyadh was previously the deputy executive director of medical and clinical affairs.