Inzerillo became the Group CEO of the The Diriyah Company in 2018, leading a $63.2 billion development project. In November 2022, DGDA announced that it was adding 16 new global hotel brands to its hospitality portfolio, bringing the total number of hotel management agreements to 34. Inzerillo previously served as the CEO of Forbes Travel Guide, president and CEO of IMG Artists, and president of the Kerzner Entertainment Group. He has also worked with brands, including One&Only Resorts, Ian Schrager Hotels, Four Seasons, and Hilton Hotels.