Kaddoumi joined Medtronic in 2012 as vice president and managing director for the Middle East and Africa and assumed his current role in October 2022. Medtronic employs 3,000 people across 102 countries in Central and Eastern Europe, the Middle East, Africa, and Russia. The company reported $5.4 billion in revenues from emerging markets and $31.7 billion in revenues globally for the 2022 financial year. In 2022, Medtronic partnered with the Ministry of Health in Saudi Arabia to establish the Diabetes Clinic. Kaddoumi has 25 years of experience in operations, services, and medical technology. He was previously president for GE Healthcare for Saudi Arabia.