Inzerillo was appointed to his current role in 2018, leading a $50.6 billion development project. In December 2021, DGDA announced 14 global hotel brands that will be opened in Diriyah, including Address Hotels & Resorts, the Hyatt Hotels Corporation, Ritz-Carlton, Raffles, the Rosewood Hotel Group, and Oberoi Hotels & Resorts. Inzerillo is also the vice-chairman of the Forbes Travel Guide, having previously been its CEO for four years. He was given a knighthood by the Knights of Malta in Rome in 1996, and he is a founding advisory board member of the Clinton AIDS Initiative.