Al-Nasr assumed his current position in July 2018. In July 2024, Equinox Hotels announced plans to open Equinox Resort Treyam in NEOM. NEOM unveiled in April 2024 that it has secured a new revolving credit facility worth $2.7 billion. Al-Nasr was previously the interim president of the King Abdullah University of Science and Technology. He began his career at Saudi Aramco in 1978