Ali founded Air Arabia in October 2003 as the first low-cost carrier in MENA. In 2023, the company recorded net profits of $421.4 million and an increase of 31% in passengers carried to reach 16.7 million passengers. In 2023, the company also expanded its global network to include 26 new routes from its seven operating hubs, bringing the group's total network size to 206 routes. The airline has a fleet of 73 aircraft. Ali is also the chairman of Information Systems Associates, T3 Aviation Academy, and Cozmo Travel, and he is a board member of Sharjah Aviation Services.