Ali founded Air Arabia in October 2003 as the first low-cost carrier in MENA. As of December 2022, the airline had a fleet of 68 aircraft, with ten being added in 2022. In 2022, the airline carried more than 12.8 million passengers from its seven hubs in the U.A.E., Morocco, Egypt, Armenia, and Pakistan, an increase of 90% compared to 2021. Air Arabia also reported a net profit of $326.8 million in 2022, an increase of 70% compared to 2021. Ali is also the chairman of Information Systems Associates, Alpha Aviation Academy, and Cozmo Travel.