Chalhoub has been president of the Etoile Group since founding the company in 1983. In October 2023, the group announced a partnership with the FAD Institute of Luxury Fashion & Style Dubai to help emerging designers and artists receive mentorship and hone their skills across the Middle East. There are currently 60 projects in progress, with plans to open new boutiques in Saudi Arabia, Bahrain, and Kuwait and reopen in Lebanon by 2025. Chalhoub is also a founding member of the UNICEF Leadership Circle, Gulf Region. She is also the ambassador for Pink Caravan and the 10KSA program and sits on the board of trustees of the Notre Dame University-Louaize’s in Lebanon.